ESR1 fusions drive endocrine therapy resistance and metastasis in breast cancer.

Published in: Molecular & cellular oncology (2018)

Estrogen receptor alpha gene (ESR1) fusion transcripts have been identified in breast cancer but their role in breast cancer is not completely understood. Here, we report a causal role for ESR1 fusions in driving both endocrine therapy resistance and metastasis, and describe a therapeutic strategy to target ESR1 fusion-induced growth.

Keyphrases

estrogen receptor
stem cells
high glucose
copy number
oxidative stress
genome wide