Body Surface Potential Mapping Detects Early Disease Onset in PKP2-Pathogenic Variant Carriers.

M Kloosterman Machteld J Boonstra R W Roudijk Mimount BourfissI van der SchaafBirgitta K Velthuis Thijs M H Eijsvogels Feddo P Kirkels Peter M van Dam Peter Loh

Published in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2023)

Assessing depolarization and repolarization by BSPM may help in the quest for early detection of disease in variant carriers since abnormal QRS- and/or STT-patterns were found in variant carriers with a normal 12-lead ECG. Because electrical abnormalities were observed in subjects with normal RV-deformation patterns, we hypothesize that electrical abnormalities develop prior to functional/structural abnormalities in ARVC.

Keyphrases

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high resolution
heart rate
heart failure
risk assessment
high density
left ventricular