Role of Liquid-Liquid Separation in Endocrine and Living Cells.

Kazuhisa AkibaYuko Katoh-FukuiKei YoshidaSatoshi NarumiMami MiyadoYukihiro HasegawaMaki Fukami

Published in: Journal of the Endocrine Society (2021)

The discovery of LLPS in cells has resulted in a paradigm shift in molecular biology. Recent studies indicate that LLPS contributes to male sex development by providing a functional platform for SOX9 and CBX2 in testicular cells. In addition, dysregulated LLPS has been implicated in aberrant protein aggregation in pancreatic β-cells, leading to type 2 diabetes. Still, we are just beginning to understand the significance of LLPS in endocrine cells.

Keyphrases

induced apoptosis
type diabetes
cell cycle arrest
living cells
stem cells
endoplasmic reticulum stress
cardiovascular disease
metabolic syndrome
small molecule
signaling pathway
cell death
high throughput
transcription factor
cell proliferation
skeletal muscle
protein protein