Impact of combinations of clinically observed HIV integrase mutations on phenotypic resistance to integrase strand transfer inhibitors (INSTIs): a molecular study.

Peter K CheungAniqa ShahidWinnie DongKatherine J LepikJulio S G MontanerMark A BrockmanZabrina L BrummeChanson J Brumme

Published in: The Journal of antimicrobial chemotherapy (2022)

High-level dolutegravir, bictegravir and cabotegravir resistance requires multiple integrase substitutions including compensatory mutations. T97A and E138K further enhance the resistance conferred by G140S/Q148H, yielding >300-fold decreased susceptibility to all INSTIs when all four mutations are present.

Keyphrases

antiretroviral therapy
hiv infected
hiv positive
hiv aids
hiv infected patients
single molecule