Kinetics and dissolution of intratracheally administered nickel oxide nanomaterials in rats.

Naohide ShinoharaGuihua ZhangYutaka OshimaToshio KobayashiNobuya ImatanakaMakoto NakaiTakeshi SasakiKenji KawaguchiMasashi Gamo

Published in: Particle and fibre toxicology (2017)

These findings suggest that nanomaterial solubility differences can result in variations in their pulmonary clearance. Nanoparticles with moderate lysosomal solubility may induce persistent pulmonary inflammation.

Keyphrases

pulmonary hypertension
oxidative stress
high intensity
oxide nanoparticles
reduced graphene oxide
walled carbon nanotubes