Actinopolymorphols E and F, pyrazine alkaloids from a marine sediment-derived bacterium Streptomyces sp.
Sohee KimPrima F HillmanJi Young LeeJuri LeeJihye LeeSun-Shin ChaDong-Chan OhSang-Jip NamWilliam FenicalPublished in: The Journal of antibiotics (2022)
HPLC-UV-guided fractionation of crude extract from the marine sediment-derived bacterium Streptomyces sp. CNP-944 has yielded two new pyrazine alkaloids, actinopolymorphols E and F (1 and 2), in addition to the previously reported biosynthetic product, actinopolymorphol G (3), and the known actinopolymorphol D (4). The chemical structures of 1-3 were determined based on the interpretation of the 1D, 2D NMR, and MS spectroscopic data. Compound 2 displayed weak antibacterial activities against Kocuria rhizophila, Bacillus subtilis, and Staphylococcus aureus with minimum inhibitory concentration (MIC) values of 16, 64, and 64 μg ml<sup>-1</sup>, respectively.
Keyphrases
- bacillus subtilis
- ms ms
- staphylococcus aureus
- heavy metals
- mass spectrometry
- high resolution
- multiple sclerosis
- magnetic resonance
- oxidative stress
- polycyclic aromatic hydrocarbons
- molecular docking
- simultaneous determination
- electronic health record
- high performance liquid chromatography
- big data
- silver nanoparticles
- risk assessment
- tandem mass spectrometry
- solid state
- biofilm formation
- machine learning
- escherichia coli
- cystic fibrosis
- liquid chromatography
- methicillin resistant staphylococcus aureus
- deep learning