Maternal polycystic ovary syndrome and risk of neuropsychiatric disorders in offspring: prenatal androgen exposure or genetic confounding?

Carolyn E CestaAnna S ÖbergAbraham IbrahimsonIkram YusufHenrik LarssonCatarina AlmqvistBrian M D'OnofrioCynthia M BulikLorena Fernández de la CruzDavid Mataix-ColsMikael LandénMina A Rosenqvist

Published in: Psychological medicine (2019)

Estimates were similar when accounting for familial confounding (i.e. genetics and environmental factors shared by cousins) and stronger in girls for ADHD and ASD, potentially indicating a differential influence of prenatal androgen exposure v. genetic factors. These results strengthen evidence for a potential causal influence of prenatal androgen exposure on the development of male-predominant neuropsychiatric disorders in female offspring of women with PCOS.

Keyphrases

polycystic ovary syndrome
pregnant women
insulin resistance
autism spectrum disorder
attention deficit hyperactivity disorder
high fat diet
genome wide
working memory
gene expression
metabolic syndrome
intellectual disability
body mass index
pregnancy outcomes
dna methylation