E3 ubiquitin ligase RNF5 protects against hepatic ischemia reperfusion injury by mediating PGAM5 ubiquitination.
Ming-Jie DingHao-Ran FangJia-Kai ZhangJi-Hua ShiXiao YuPei-Hao WenZhi-Hui WangSheng-Li CaoYi ZhangXiao-Yi ShiHua-Peng ZhangYu-Ting HeBing YanHong-Wei TangDan-Feng GuoJie GaoZhen LiuLi ZhangShui-Jun ZhangXiao-Jing ZhangWen-Zhi GuoPublished in: Hepatology (Baltimore, Md.) (2021)
We revealed that RNF5 protected against HIR via its interaction with PGAM5 to inhibit the activation of ASK1 and the downstream JNK/p38 signaling cascade. Our findings indicate that the RNF5-PGAM5 axis may be a promising therapeutic target for HIR.