Botanical Drug Puerarin Ameliorates Liposaccharide-Induced Depressive Behaviors in Mice via Inhibiting RagA/mTOR/p70S6K Pathways.

Jia ZhaoYizhen JiaWei ZhaoHuixin ChenXiuying ZhangFung Yin NgoDan LuoYou-Qiang Song Li-Xing Lao Jianhui Rong

Published in: Oxidative medicine and cellular longevity (2021)

Botanical drug puerarin attenuated inflammation and depressive behaviors in LPS-challenged mice by inhibiting RagA/mTOR/p70S6K pathways. Puerarin may be a lead compound for the new antidepressant drugs.

Keyphrases

drug induced
high fat diet induced
bipolar disorder
signaling pathway
cell proliferation
major depressive disorder
oxidative stress
stress induced
high glucose
inflammatory response
diabetic rats
adverse drug
insulin resistance
endothelial cells
emergency department