Genotype-specific spinal cord damage in spinocerebellar ataxias: an ENIGMA-Ataxia study.
Thiago Junqueira Ribeiro de RezendeIsaac AdanyaguhOrlando G P BarsottiniBenjamin BenderFernando CendesLéo CoutinhoAndreas DeistungImis DoganAlexandra DurrJuan Fernandez-RuizSophia L GörickeMarina GrisoliCarlos R Hernandez-CastilloChristophe LengletCaterina MariottiAlberto Rolim Muro MartinezBreno K MassuyamaFanny MochelLorenzo NanettiAnna NigriSergio E OnoGülin ÖzJosé Luiz PedrosoKathrin ReetzMatthis SynofzikHelio TeiveSophia I ThomopoulosPaul M ThompsonDagmar TimmannBart P C van de WarrenburgJudith van GaalenMarcondes Cavalcante de França JuniorIan H HardingPublished in: Journal of neurology, neurosurgery, and psychiatry (2024)
Spinal cord abnormalities are an early and progressive feature of SCA1, SCA2 and SCA3, but not SCA6, which can be captured using quantitative MRI.