IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy.
Georgette TannerRhiannon BarrowShoaib AjaibMuna Al-JabriNazia AhmedSteven PollockMartina FinettiNora RippausAlexander F BrunsKhaja SyedJames A PoulterLaura MatthewsThomas HughesErica WilsonColin JohnsonFrederick S VarnAnke Brüning-RichardsonCatherine HoggAlastair DroopArief GusnantoMatthew A CareLuisa CutilloDavid R WestheadSusan C ShortMichael D JenkinsonAndrew BrodbeltAruna ChakrabartyAzzam IsmailRoel G W VerhaakLucy F SteadPublished in: Genome biology (2024)
We show that the responder subtype is cancer-cell intrinsic, recapitulated in in vitro GBM cell models, and influenced by the presence of the tumor microenvironment. Stratifying GBM tumors by responder subtype may lead to more effective treatment.