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Mincle-GSDMD-mediated release of IL-1β small extracellular vesicles from hepatic macrophages in ethanol-induced liver injury.

Quanri ZhangWeiwei LiuKatarzyna BulekHan WangMegan R McMullenXiaoqin WuNicole WelchRenliang ZhangJaividhya DasarathySrinivasan DasarathyLaura E NagyXiaoxia Li
Published in: Hepatology communications (2023)
β-GluCer functions as a danger-associated molecular pattern activating Mincle-dependent gasdermin D-mediated formation and release of IL-1β-containing sEVs, which in turn exacerbate hepatocyte cell death and contribute to the pathogenesis of ALD.
Keyphrases
  • cell death
  • signaling pathway
  • fluorescent probe
  • living cells
  • liver injury