Mincle-GSDMD-mediated release of IL-1β small extracellular vesicles from hepatic macrophages in ethanol-induced liver injury.
Quanri ZhangWeiwei LiuKatarzyna BulekHan WangMegan R McMullenXiaoqin WuNicole WelchRenliang ZhangJaividhya DasarathySrinivasan DasarathyLaura E NagyXiaoxia LiPublished in: Hepatology communications (2023)
β-GluCer functions as a danger-associated molecular pattern activating Mincle-dependent gasdermin D-mediated formation and release of IL-1β-containing sEVs, which in turn exacerbate hepatocyte cell death and contribute to the pathogenesis of ALD.