Improvement of Paclitaxel-Associated Adverse Reactions (ADRs) via the Use of Nano-Based Drug Delivery Systems: A Systematic Review and Network Meta-Analysis.

Pi-Ling ChouYa-Ping Huang Meng-Hsuan ChengKun-Ming RauYi-Ping Fang

Published in: International journal of nanomedicine (2020)

Nano-based paclitaxel delivery resulted in fewer hypersensitivity reactions than solvent-based delivery. However, the incidence of neutropenia and leucopenia was higher in nano-based than solvent-based paclitaxel delivery. Dose-dependent ADRs were more frequent in paclitaxel anticancer treatment.

Keyphrases

chemotherapy induced
risk factors
combination therapy