Muscle mass affects paclitaxel systemic exposure and may inform personalized paclitaxel dosing.
Daniel Louis HertzLi ChenNorah L HenryJennifer J GriggsDaniel F HayesBrian A DerstineGrace L SuStewart C WangManjunath Amit P PaiPublished in: British journal of clinical pharmacology (2022)
Extending paclitaxel infusion duration in ~25% of patients who have low skeletal muscle area is predicted to reduce peripheral neuropathy while maintaining systemic exposure, suggesting that personalizing paclitaxel dosing based on body composition may improve treatment outcomes.