Asthma and its relationship to mitochondrial copy number: Results from the Asthma Translational Genomics Collaborative (ATGC) of the Trans-Omics for Precision Medicine (TOPMed) program.

Maxwell P CoccoEvan WhiteShujie XiaoDonglei HuAngel MakPatrick SleimanMao YangKevin R BobbittHongsheng GuiAlbert M LevinSamantha HochstadtKyle WhitehouseDean RynkowskiAndrea J BarczakGonçalo AbecasisThomas W BlackwellHyun Min KangDeborah A NickersonSoren GermerJun DingDavid E LanfearFrank GillilandW James GaudermanRajesh KumarDavid J ErleFernando MartinezHakon HakonarsonEsteban G BurchardL Keoki Williams

Published in: PloS one (2020)

We observed a robust association between asthma and higher mitochondrial copy number. Asthma having an effect on mitochondria function was also supported by lower respiratory complex gene expression in this group.

Keyphrases

copy number
mitochondrial dna
chronic obstructive pulmonary disease
lung function
gene expression
genome wide
dna methylation
allergic rhinitis
oxidative stress
quality improvement
cystic fibrosis
air pollution
cell death