Increased Remnant Lipoproteins in Apo E Deficient Mice Induce Coronary Atherosclerosis following Transverse Aortic Constriction and Aggravate the Development of Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure.
Ilayaraja MuthuramuMudit MishraBart De GeestPublished in: Biomedicines (2022)
Murine coronary arteries are very resistant to the development of atherosclerosis, which may be related to their intramyocardial course. Blood pressure promotes atherosclerotic plaque formation by acting as a physical force that potentiates the migration of pro-atherogenic lipoproteins across the endothelium. C57BL/6N apolipoprotein (apo) E deficient mice have increased remnant lipoproteins that are a risk factor for coronary atherosclerosis. In this study, our aim was to quantify coronary atherosclerosis and artery remodeling following transverse aortic constriction (TAC) in C57BL/6N apo E -/- mice and to evaluate the impact of increased remnant lipoproteins on the development of pressure overload-induced cardiac hypertrophy and heart failure. Advanced atherosclerotic lesions were observed in the left coronary artery of C57BL/6N apo E -/- TAC mice but not in C57BL/6N TAC mice. Pressure overload resulted in markedly increased cardiac hypertrophy and more pronounced heart failure in C57BL/6N apo E -/- TAC mice in comparison to C57BL/6N TAC mice. Pathological hypertrophy, as evidenced by increased myocardial fibrosis and capillary rarefaction, was more prominent in C57BL/6N TAC apo E -/- than in C57BL/6N TAC mice and led to more marked cardiac dysfunction. In conclusion, TAC in apo E deficient mice induces coronary atherosclerosis and aggravates the development of pathological cardiac hypertrophy and heart failure.
Keyphrases
- coronary artery
- heart failure
- coronary artery disease
- left ventricular
- high fat diet induced
- pulmonary artery
- cardiovascular disease
- blood pressure
- physical activity
- wild type
- aortic stenosis
- atrial fibrillation
- oxidative stress
- aortic valve
- cardiac resynchronization therapy
- neuropathic pain
- nitric oxide
- mental health
- type diabetes
- pulmonary hypertension
- skeletal muscle
- single molecule
- endothelial cells
- transcatheter aortic valve replacement
- stress induced
- drug induced
- pulmonary arterial hypertension
- blood glucose
- blood flow
- aortic dissection