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Hypoxia-Inducible Factor and Oxidative Stress in Tendon Degeneration: A Molecular Perspective.

Hamzah ShahidVivek Kumar MoryaJi-Ung OhJae-Hyung KimKyu-Cheol Noh
Published in: Antioxidants (Basel, Switzerland) (2024)
Tendinopathy is a debilitating condition marked by degenerative changes in the tendons. Its complex pathophysiology involves intrinsic, extrinsic, and physiological factors. While its intrinsic and extrinsic factors have been extensively studied, the role of physiological factors, such as hypoxia and oxidative stress, remains largely unexplored. This review article delves into the contribution of hypoxia-associated genes and oxidative-stress-related factors to tendon degeneration, offering insights into potential therapeutic strategies. The unique aspect of this study lies in its pathway-based evidence, which sheds light on how these factors can be targeted to enhance overall tendon health.
Keyphrases
  • oxidative stress
  • dna damage
  • diabetic rats
  • endothelial cells
  • induced apoptosis
  • mental health
  • gene expression
  • risk assessment
  • human health
  • single molecule
  • heat stress
  • genome wide analysis