Management of partial and non-responding cutaneous squamous cell carcinoma.
Philipp JansenGeorg LoddeK G GriewankE HadaschikAlexander RoeschS UgurelL ZimmerE LivingstoneDirk SchadendorfPublished in: Journal of the European Academy of Dermatology and Venereology : JEADV (2021)
Cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma are the most common types of skin cancer. For patients with locally advanced and metastatic cSCC, the programmed cell death 1 (PD-1) inhibitor cemiplimab is approved for systemic treatment. Despite this revolutionary immunomodulatory therapeutic approach, tumours may fail to respond either completely or partially. In addition to the previously established local treatment with radiotherapy or systemic treatment with chemotherapy and epidermal growth factor receptor inhibitors, ongoing trials are currently focussed on re-stimulating the antitumour immune response in patients with advanced cSCC refractory to PD-1 inhibitors. In this review, ongoing and recently finished trials with different therapeutic approaches will be discussed.
Keyphrases
- squamous cell carcinoma
- locally advanced
- epidermal growth factor receptor
- immune response
- radiation therapy
- rectal cancer
- small cell lung cancer
- neoadjuvant chemotherapy
- early stage
- lymph node metastasis
- advanced non small cell lung cancer
- phase ii study
- skin cancer
- lymph node
- dendritic cells
- radiation induced
- inflammatory response
- drug induced