Genomic Biomarkers Associated with Response to Induction Chemotherapy in Patients with Localized Pancreatic Ductal Adenocarcinoma.

Brett L Ecker Alice J Tao Quisette P Janssen Henry S Walch Colin M Court Vinod P Balachandran Christopher H Crane Michael I D'Angelica Jeffrey A Drebin Thomas Peter Kingham Kevin C Soares Christine A Iacobuzio-Donahue Efsevia Vakiani Mithat Gönen Eileen M O'Reilly Marjorie G Zauderer William R Jarnagin Alice C Wei

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

SMAD4 alterations were associated with more frequent development of metastasis and lower probability of reaching surgical resection during neoadjuvant FOLFIRINOX but not gemcitabine/nab-paclitaxel. Confirmation in a larger, diverse patient cohort will be important before prospective evaluation of SMAD4 as a genomic biomarker to guide treatment selection.

Keyphrases

locally advanced
rectal cancer
epithelial mesenchymal transition
squamous cell carcinoma
transforming growth factor
radiation therapy
copy number
case report
lymph node
gene expression
signaling pathway
dna methylation
combination therapy
replacement therapy
chemotherapy induced
tyrosine kinase