Autophagy activation mediates resistance to FLT3 inhibitors in acute myeloid leukemia with FLT3-ITD mutation.

Dan XuYishan ChenYing YangZhao YinChangfen HuangQiang WangLing JiangXuejie JiangChangxin YinQifa LiuGuo-Pan Yu

Published in: Journal of translational medicine (2022)

Autophagy might be stimulated by acquired mutation or BME, and bypass activate FLT3 downstream signaling to mediate FLT3 inhibitor resistance in FLT3-ITD-positive AML. Targeting autophagy could be a promising strategy to overcome resistance.

Keyphrases

acute myeloid leukemia
allogeneic hematopoietic stem cell transplantation
cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
tyrosine kinase
cancer therapy
drug delivery