Early Onset Intrahepatic Cholangiocarcinoma: Clinical Characteristics, Oncological Outcomes, and Genomic/Transcriptomic Features.
Diamantis I TsilimigrasXu HanAlfredo GuglielmiLuca AldrighettiMatthew WeissTodd W BauerSorin AlexandrescuGeorge A PoultsidesShishir K MaithelHugo P MarquesGuillaume MartelCarlo PulitanoFeng ShenFrançois ChaucyBas Groot KoerkampItaru EndoKazunari SasakiFederico AucejoXu-Feng ZhangHua ZhuTimothy M PawlikPublished in: Annals of surgical oncology (2024)
Early-onset ICC has distinct clinical and genomic/transcriptomic features. Morphologic and clinicopathologic characteristics were unable to fully explain differences in outcomes among early versus typical onset ICC patients. The current study offers a preliminary landscape of the molecular features of early-onset ICC.
Keyphrases
- early onset
- late onset
- single cell
- end stage renal disease
- newly diagnosed
- ejection fraction
- copy number
- rna seq
- peritoneal dialysis
- prognostic factors
- prostate cancer
- rectal cancer
- metabolic syndrome
- gene expression
- patient reported outcomes
- radical prostatectomy
- adipose tissue
- robot assisted
- dna methylation
- single molecule
- insulin resistance
- genome wide