Differentiated Cells in Prolonged Hypoxia Produce Highly Infectious Native-Like Hepatitis C Virus Particles.

Jade CochardAnne Bull-MaurerClovis TauberJulien Burlaud GaillardFrédéric MazurierJean-Christophe MeunierPhilippe RoingeardPhilippe Chouteau

Published in: Hepatology (Baltimore, Md.) (2021)

This relevant HCV cell culture model thus mimics the complete native intracellular HCV life cycle and, by extension, can be proposed as a model of choice for studies of other hepatotropic viruses.

Keyphrases

hepatitis c virus
human immunodeficiency virus
life cycle
induced apoptosis
cell cycle arrest
endothelial cells
cell death
oxidative stress
endoplasmic reticulum stress
signaling pathway
case control
pi k akt