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Identification of Genes Hub Associated with Triple-Negative Breast Cancer and Cannabidiol Analogs Potential Inhibitory Agents: An In-silico Study.

Neyder ContrerasAntistio Alviz-AmadorJaner Andres Zabaleta-GuzmanRafael Pineda AlemanArnulfo Tarón Dunoyer
Published in: Asian Pacific journal of cancer prevention : APJCP (2024)
In conclusion, this study identified key genes, namely RPL7A, NHP2L1, and PSMD11, associated with triple-negative breast cancer and demonstrated promising interactions with cannabidiol analogs, particularly 44409296 and 166505341. These findings suggest potential therapeutic targets and highlight the relevance of further clinical investigations. Additionally, the ligands exhibited favorable ADME properties and low toxicity, underscoring their potential in future drug development for TNBC treatment.
Keyphrases
  • molecular docking
  • bioinformatics analysis
  • genome wide
  • human health
  • oxidative stress
  • gene expression
  • risk assessment
  • current status
  • climate change
  • genome wide identification