Impact of one versus two doses of mesenchymal stromal cells on lung and cardiovascular repair in experimental emphysema.

Hananda A PoggioMariana A AntunesNazareth N RochaJamil Z KitokoMarcelo M MoralesPriscilla C OlsenMiquéias Lopes-PachecoFernanda F CruzPatricia Rieken Macêdo Rocco

Published in: Stem cell research & therapy (2018)

Two doses of MSCs enhanced lung repair and improvement in cardiac function, while inducing T cell immunosuppression, mainly of CD8+ cells, in elastase-induced emphysema.

Keyphrases

chronic obstructive pulmonary disease
induced apoptosis
lung function
cell cycle arrest
mesenchymal stem cells
idiopathic pulmonary fibrosis
pulmonary fibrosis
bone marrow
high glucose
diabetic rats
oxidative stress
cell death
nk cells