Single-cell Multiomics Analysis of Myelodysplastic Syndromes and Clinical Response to Hypomethylating Therapy.

Ignacio Campillo-Marcos Marta Casado-Pelaez Veronica Davalos Gerardo Ferrer Caterina Mata Elisabetta Mereu Gael Roué David Valcarcel Antonieta Molero Lurdes Zamora Blanca Xicoy Cirici Laura Palomo Pamela Acha Ana Manzanares Magnus Tobiasson Eva Hellström Lindberg Francisco Solé Manel Esteller

Published in: Cancer research communications (2024)

MDS are myeloid clonal hemopathies with a low 5-year survival rate, and approximately half of the cases do not respond to standard HMA therapy. Our innovative single-cell multiomics approach offers valuable biological insights and potential biomarkers associated with the demethylating agent efficacy. It also identifies vulnerabilities that can be targeted using personalized combinations of small drugs and antibodies.

Keyphrases

single cell
rna seq
high throughput
dendritic cells
acute myeloid leukemia
stem cells
cancer therapy
immune response
cell therapy
mesenchymal stem cells