Calciprotein particle counts associate with vascular remodelling in chronic kidney disease.
Lian FeenstraMelanie ReijrinkAndreas PaschEdward R SmithLotte M VisserMarian BulthuisMonique E LodewijkMirjam F MastikMarcel J W GreuterRiemer H J A SlartDouwe Johannes MulderRobert A PolCharlotte A Te Velde-Keyzernull nullGuido KrenningJan-Luuk HillebrandsPublished in: Cardiovascular research (2024)
Our findings reveal that CKD is characterized by systemic VC with increased calcification propensity and CPP counts. Transcriptome profiling showed altered vascular gene expression with enrichment for endothelial activation, inflammation, ECM remodelling and ossification. Moreover, we demonstrate for the first time that vascular remodelling processes are associated with increased circulating CPP counts. Interventions targeting CPPs are promising avenues for alleviating vascular remodelling and VC in CKD.