N-staging in large cell neuroendocrine carcinoma of the lung: diagnostic value of [18F]FDG PET/CT compared to the histopathology reference standard.

Hubertus HautzelYazan AlnajdawiWolfgang P FendlerChristoph RischplerKaid DarwicheWilfried E EberhardtLale UmutluDirk TheegartenMartin StuschkeMartin SchulerClemens AignerKen HerrmannTill Plönes

Published in: EJNMMI research (2021)

In LCNEC N-staging with [18F]FDG PET/CT demonstrates both high sensitivity and specificity, an excellent NPV but a slightly reduced PPV. Accordingly, preoperative invasive mediastinal staging may be omitted in cases with cN0 disease by [18F]FDG PET/CT. In [18F]FDG PET/CT cN1-cN3 stages histological confirmation is warranted, particularly in case of only moderate [18F]FDG uptake as compared to the LCNEC primary.

Keyphrases

lymph node
pet ct
lymph node metastasis
single cell
squamous cell carcinoma
patients undergoing
high intensity
cell therapy
pet imaging
stem cells
computed tomography