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The dietary protein paradox and threonine 15 N-depletion: Pyridoxal-5'-phosphate enzyme activity as a mechanism for the δ15 N trophic level effect.

Benjamin T FullerKlaus J Petzke
Published in: Rapid communications in mass spectrometry : RCM (2018)
The 15 N-depleted results of threonine are linked to increased activity of threonine ammonia-lyase, and show potential as a possible biomarker for protein intake and/or gluconeogenesis. We hypothesize that the inverse nitrogen equilibrium isotope effects of Schiff base formation, between AAs and pyridoxal-5'-phosphate cofactor enzymes, play a key role in the bioaccumulation and depletion of 15 N in the biomolecules of living organisms and contributes to the variability in the nitrogen trophic level effect. Copyright © 2017 John Wiley & Sons, Ltd.
Keyphrases
  • protein kinase
  • heavy metals
  • amino acid
  • human health
  • binding protein
  • molecular dynamics
  • risk assessment
  • room temperature
  • physical activity
  • mass spectrometry
  • weight gain
  • climate change
  • high resolution