N6-methyladenosine mRNA methylation of PIK3CB regulates AKT signalling to promote PTEN-deficient pancreatic cancer progression.

Jianbo TianYing ZhuMeilin RaoYimin CaiZequn LuDanyi ZouXiating PengPingting YingMing ZhangSiyuan NiuYue LiRong ZhongJiang Chang Xiaoping Miao

Published in: Gut (2020)

These findings demonstrate aberrant m6A homoeostasis as an oncogenic mechanism in PDAC and highlight the potential of PIK3CB as a therapeutic target for this disease.

Keyphrases

cell proliferation
signaling pathway
pi k akt
dna methylation
genome wide
transcription factor
human health
risk assessment
climate change