Long-term outcomes after new onset seizure in children living with HIV: A cohort study.
Gretchen L BirbeckMusaku MwenechanyaIfunanya Ume-EzeokeManoj MathewsChristopher M BositisLisa KalungwanaDavid BeardenMelissa ElafrosHarris A GelbardWilliam H TheodoreIgor J KoralnikJason F OkuliczBrent A JohnsonNamwiya MusondaOmar K SiddiqiMichael J PotchenIzukanji SikazwePublished in: Epilepsia open (2024)
This study followed CLWH who experienced a new onset seizure to find out how many go on to have more seizures and identify any patient characteristics associated with having more seizures. The study found that mortality rates continue to be high beyond the acute clinical presentation with new onset seizure. Children with a CNS OI causing the new onset seizure had a lower risk of later seizures, possibly because the trigger for the seizure can be treated. In contrast, high functioning children without a CNS OI were at higher risk of future seizures.