Tumor suppressive role of the antimicrobial lectin REG3A targeting the O -GlcNAc glycosylation pathway.
Nicolas MoniauxNicolas GeoffreAlice DeshayesAlexandre Dos SantosSylvie JobClaire LacosteTung-Son NguyenMarion DarnaudMélanie Friedel-ArboleasCatherine GuettierJanne PurhonenJukka KallijärviGilles AmouyalPaul AmouyalChristian BréchotRomain R VivèsMarie Annick BuendiaTarik IssadJamila FaivrePublished in: Hepatology (Baltimore, Md.) (2024)
REG3A helps fight liver cancer by reducing O -GlcNAcylation. This study suggests a new paradigm for the regulation of O -GlcNAc signaling in cancer-related pathways through interactions with the carbohydrate-binding function of REG3A.