Utilization of endogenous albumin trafficking pathways in the lungs has potential to modestly increase the lung interstitial access and absorption of drug delivery systems after inhaled administration.
Jibriil P IbrahimNeville J ButcherAshok KothapalliChristopher N SubasicJoanne T BlanchfieldAndrew K WhittakerMichael Raymond WhittakerLisa M KaminskasPublished in: Expert opinion on drug delivery (2023)
Drug delivery systems that bind endogenous albumin may show a modest increase in lung permeability and absorption after inhaled delivery compared to systems that do not efficiently bind albumin.