Increase in Endogenous Glucose Production With SGLT2 Inhibition Is Unchanged by Renal Denervation and Correlates Strongly With the Increase in Urinary Glucose Excretion.
Carolina Solis-HerreraGiuseppe DanieleMariam AlatrachChristina AgyinCurtis TriplittJohn AdamsRupal PatelFrancesco RubinoHenri HonkaXi ChenMuhammad Abdul-GhaniEugenio CersosimoStephano Del PratoRalph A De FronzoPublished in: Diabetes care (2020)
Renal denervation in patients who received a kidney transplant failed to block the DAPA-mediated stimulation of EGP in both individuals with T2D and non-DM subjects. The DAPA-stimulated rise in EGP is strongly related to the increase in UGE, blunting the decline in FPG.