In vitro characterization of neonatal, juvenile, and adult porcine islet oxygen demand, β-cell function, and transcriptomes.
Kate E SmithWilliam G PurvisMelissa A DavisCatherine G MinAmanda M CookseyCraig S WeberJana JandovaNicholas D PriceDiana S MolanoJames Brett StantonAmy C KellyLeah V SteynRonald M LynchSean W LimesandMichael AlexanderJonathan R T LakeyKaren SeebergerGregory S KorbuttKate R MuellerBernhard J HeringFiona M McCarthyKlearchos K PapasPublished in: Xenotransplantation (2018)
The oxygen demand, membrane integrity, β-cell function and proliferation, and transcriptomes of islets from API, JPI, and NPI provide a comprehensive physiological comparison for future studies. These assessments will inform the optimal application of each age of porcine islet to expand the availability of islet transplantation.