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Molecular Mechanisms to Target Cellular Senescence in Aging and Disease.

Serena MarcozziAntonio Paolo BeltramiMarco Malavolta
Published in: Cells (2022)
Cellular senescence is a state of irreversible cell cycle arrest in response to several stressors, including DNA damage, increased cellular oxidative stress, telomere shortening, oncogene activation, and a deep epigenetic remodeling [...].
Keyphrases
  • dna damage
  • oxidative stress
  • cell cycle arrest
  • dna repair
  • cell death
  • endothelial cells
  • pi k akt
  • gene expression
  • ischemia reperfusion injury
  • induced apoptosis
  • signaling pathway