P2Y12 inhibitor use predicts hematoma expansion in patients with intracerebral hemorrhage.
Ethan J HouskampYuzhe LiuJuliana Silva Pinheiro do NascimentoBabak S JahromiPaul F LindholmHau C KwaanAndrew M NaidechPublished in: Annals of clinical and translational neurology (2024)
Patients taking a P2Y12 inhibitor had more HE and less P2Y12 activity. The effect was most pronounced in patients on DAPT, suggesting a synergistic effect of P2Y12 inhibitors and aspirin with respect to HE. Acute reversal of P2Y12 inhibitors in acute ICH requires further study.
Keyphrases
- end stage renal disease
- ejection fraction
- chronic kidney disease
- liver failure
- prognostic factors
- low dose
- peritoneal dialysis
- cardiovascular disease
- antiplatelet therapy
- patient reported outcomes
- acute coronary syndrome
- drug induced
- hepatitis b virus
- percutaneous coronary intervention
- cardiovascular events
- atrial fibrillation
- cancer therapy
- acute respiratory distress syndrome