Little Evidence of Modified Genetic Effect of rs16969968 on Heavy Smoking Based on Age of Onset of Smoking.
Christine AdjangbaRichard BorderPamela N Romero VillelaMarissa A EhringerLuke M EvansPublished in: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco (2021)
We failed to replicate the strong rs16969968 × AOS interaction effect on smoking quantity previously reported. If such gene-moderator interactions influence complex traits, current biobanks lack the power to detect significant genome-wide associations given the minute effect sizes expected. Furthermore, many potential interaction effects are likely to depend on the scale of measurement employed.