Isoginkgetin treatment attenuated lipopolysaccharide-induced monoamine neurotransmitter deficiency and depression-like behaviors through downregulating p38/NF-κB signaling pathway and suppressing microglia-induced apoptosis.
Peng LiFucheng ZhangYajuan LiCai ZhangZhiyou YangYongping ZhangCai ZhangPublished in: Journal of psychopharmacology (Oxford, England) (2021)
These data demonstrate that isoginkgetin is an effective therapeutic agent for depression-like behaviors and neuropathological changes via potent anti-inflammatory property.
Keyphrases
- signaling pathway
- induced apoptosis
- lipopolysaccharide induced
- inflammatory response
- anti inflammatory
- pi k akt
- epithelial mesenchymal transition
- depressive symptoms
- oxidative stress
- endoplasmic reticulum stress
- lps induced
- sleep quality
- replacement therapy
- big data
- electronic health record
- spinal cord
- spinal cord injury
- cell proliferation
- physical activity