Altered DNA methylation in liver and adipose tissues derived from individuals with obesity and type 2 diabetes.

Francisco Barajas-OlmosFederico Centeno-CruzCarlos ZerrweckIván Imaz-RosshandlerAngélica Martínez-HernándezEmilio J CordovaClaudia Rangel-EscareñoFaustino GálvezArmando CastilloHernán MaydónFrancisco CamposDiana Gabriela Maldonado-PintadoLorena Orozco-Orozco

Published in: BMC medical genetics (2018)

Our present findings provide additional evidence that aberrant DNA methylation may be a relevant mechanism involved in T2D pathogenesis among individuals with obesity.

Keyphrases

dna methylation
type diabetes
insulin resistance
gene expression
metabolic syndrome
weight loss
high fat diet induced
genome wide
adipose tissue
weight gain
glycemic control
skeletal muscle
copy number