Synthesis of 5-Methylene-2-pyrrolones.

Marco Paolo JacintoPatricio PichlingMarc M Greenberg

Published in: Organic letters (2018)

A facile, one-pot synthetic method for the synthesis of 5-methylene-2-pyrrolones (5MPs) from inexpensive furfuryl acetate is described. Bromine oxidation and trapping of the in situ generated 1,4-dicarbonyl compound by a primary amine provided the corresponding 5MPs in 50-69% yield.

Keyphrases

hydrogen peroxide
quantum dots
highly efficient