Factor VIII inhibitor development in Egyptian hemophilia patients: does intron 22 inversion mutation play a role?
Laila M SheriefOsama A GaberHala Mosaad YoussefHanan S SherbinyWesam A MokhtarAsmaa A A AliNaglaa M KamalYehia H Abdel MaksoudPublished in: Italian journal of pediatrics (2020)
The prevalence of Inv22 of F VIII in Egyptian hemophiliacs is nearly like that of other population. This mutation was more frequently detected among severe hemophilic patients as compared with moderately affected peers. The presence of Inv22 mutation significantly predispose to FVIII inhibitor development.