Silencing PinX1 enhances radiosensitivity and antitumor-immunity of radiotherapy in non-small cell lung cancer.
Jieping QiuYing XiaYawei BaoJingjing ChengLei LiuDong QianPublished in: Journal of translational medicine (2024)
In NSCLC, silencing PinX1 significantly contributed to the radiosensitivity and promoted the efficacy of radioimmunotherapy. Mechanistically, PinX1 may regulate the transport of telomerase to telomeres through interacting with RBM10, which promotes telomere maintenance and DNA stabilization. Our findings reveal that PinX1 is a potential target to enhance the efficacy of radioimmunotherapy in NSCLC patients.
Keyphrases
- small cell lung cancer
- end stage renal disease
- ejection fraction
- advanced non small cell lung cancer
- newly diagnosed
- chronic kidney disease
- early stage
- peritoneal dialysis
- prognostic factors
- gene expression
- genome wide
- single molecule
- circulating tumor
- radiation induced
- cell free
- epidermal growth factor receptor
- locally advanced
- tyrosine kinase