Exploring the impact of hippocampal sclerosis on white matter tracts memory in individuals with mesial temporal lobe epilepsy.

Tamires Araújo ZanãoJohanna Seitz-HollandLauren J O'DonnellFan ZhangYogesh RathiTátila M LopesLuciana Ramalho Pimentel-SilvaClarissa L YassudaNikos MakrisMartha E ShentonSylvain BouixAmanda E LyallFernando Cendes

Published in: Epilepsia open (2023)

Our results highlight that the presence and side of HS are crucial to understand the pathophysiology of MTLE. Specifically, left-sided HS seems to be related to widespread bilateral white matter abnormalities. Future longitudinal studies should focus on developing diagnostic and treatment strategies dependent on HS's presence/side.

Keyphrases

temporal lobe epilepsy
white matter
multiple sclerosis
current status
working memory
case control
drug induced