A Mammalian Target of Rapamycin-Perilipin 3 (mTORC1-Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis.

Marina García MaciaAdrián Santos-LedoJack LeslieHannah L PaishAmy L CollinsRebecca S ScottAbigail WatsonRachel A BurgoyneSteve WhiteJeremy FrenchJohn HammondLee A BorthwickJelena MannJuan P BolañosViktor I KorolchukFiona OakleyDerek A Mann

Published in: Hepatology (Baltimore, Md.) (2021)

These results reveal that mTORC1 regulates liver lipophagy through a mechanism dependent on Plin3 phosphorylation. We propose that stimulating this pathway can enhance lipophagy in hepatocytes to help protect the liver from lipid-mediated toxicity, thus offering a therapeutic strategy in NAFLD.

Keyphrases

genome wide
dna methylation
protein kinase