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Clinicopathologic Findings in Patients With Paraneoplastic Neuropathies and Antibodies Strongly Associated With Cancer.

Andre GrangerTina RajnauthRajat LahoriaDivyanshu DubeyJohn R MillsMichelle L MauermannSarah E BeriniRobert J SpinnerP James B DyckChristopher J Klein
Published in: Neurology (2023)
Axonal loss, subperineurial edema, and an absence of prominent inflammation are the most common findings in nerve biopsies of patients with paraneoplastic antibodies strongly associated with cancer. The LRPN phenotype was the only subset with inflammatory collections. Paraneoplastic autoantibody testing should be considered in patients with subacute onset neuropathies, with or without interstitial inflammatory findings.
Keyphrases
  • papillary thyroid
  • oxidative stress
  • squamous cell
  • lymph node metastasis
  • childhood cancer
  • peripheral nerve