HMGB1/autophagy pathway mediates the atrophic effect of TGF-β1 in denervated skeletal muscle.
Xiaofan YangPingping XueXin LiuXiang XuZhenbing ChenPublished in: Cell communication and signaling : CCS (2018)
Thus, our data revealed that TGF-β1 is a vital regulatory factor in denervated skeletal muscle in which HMGB1/ autophagy pathway mediates the atrophic effect of TGF-β1. Our findings confirmed a new pathway in denervation-induced skeletal muscle atrophy and it may be a novel therapeutic target for patients with muscle atrophy after peripheral nerve injury.