Differential impact of paired patient-derived BPH and normal adjacent stromal cells on benign prostatic epithelial cell growth in 3D culture.

Wei ChenLaura E PascalKe WangRajiv DhirAlexa M SimsRobert CampbellGwenyth GasperDonald B DeFrancoNaoki YoshimuraZhou Wang

Published in: The Prostate (2020)

These findings suggest that the stromal cells in BPH tissues are different from normal adjacent stromal cells and could promote epithelial cell proliferation, potentially contributing to the development and progression of BPH.

Keyphrases

benign prostatic hyperplasia
lower urinary tract symptoms
cell proliferation
gene expression
cell cycle
pi k akt
signaling pathway