Altered brain white matter structural motor network in spinocerebellar ataxia type 3.

Xin-Yuan ChenZi-Qiang HuangWei LinMeng-Cheng LiZhi-Xian YeYu-Sen QiuXiao-Yue XiaNa-Ping ChenJian-Ping HuShi-Rui Gan Qun-Lin Chen

Published in: Annals of clinical and translational neurology (2022)

Changes to the WM motor network in SCA3 start before ataxia onset, and WM motor network involvement increases with disease progression. Global network topological measures of the WM motor network appear to be a promising image biomarker for disease severity. This study provides new insights into the pathophysiology of disease in SCA3/MJD.

Keyphrases

white matter
deep learning
multiple sclerosis
machine learning