Characteristics of patients with Atrial Fibrillation treated with direct oral anticoagulants and New Insights into inappropriate dosing: Results from the French National PAF Registry.

M GuenounS CohenM Villaceque A Sharareh J C DibJ ScwartzO HoffmannL OuazanaS AssoulineE ParrensT GarbanV PradeauD Guedj-MeynierB Lequeux C CohenP DurandFrançois Diévart Tarvinder S Dhanjal Pierre Sabouret Nicolas Lellouche

Published in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2023)

Within this large registry, DOACs were associated with inappropriate dosing in 18% of cases. Independent predictors of inappropriate dosing were high CHA2DS2VASc scores and older age. Moreover, 46% of patients treated with low dose DOACs were inappropriately underdosed and more frequently occurred with apixaban.

Keyphrases

direct oral anticoagulants
atrial fibrillation
venous thromboembolism
low dose
high dose
physical activity
quality improvement
community dwelling
newly diagnosed