Carvacrol protects the ARPE19 retinal pigment epithelial cells against high glucose-induced oxidative stress, apoptosis, and inflammation by suppressing the TRPM2 channel signaling pathways.

Hatice Daldal Mustafa Nazıroğlu

Published in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2022)

influx and oxidative retinal toxicity in the ARPE19 cells were induced by the stimulation of TRPM2, although they were modulated via the inhibition of TRPM2 by CRV. CRV may be noted as a potential therapeutic antioxidant to the TRPM2 activation-mediated retinal oxidative injury.

Keyphrases

oxidative stress
induced apoptosis
high glucose
cell cycle arrest
optical coherence tomography
diabetic retinopathy
endothelial cells
signaling pathway
endoplasmic reticulum stress
pi k akt
cell death
optic nerve
hydrogen peroxide
nitric oxide